Detection of KPC-producing Enterobacteriaceae among Hospitalized patients with phenotypic method in Shahid Modarres Hospital, Tehran, Iran

Enterobacteriaceae spp. are an important part of agents that cause infection in health care facilities.Due to Importance of monitoring and management of drug resistance in health care facilities, especially for preventing of dissemination of new resistances such as KPC producing enterobacteriaceae, in this study KPC producer Enterobacteriaceae in hospital departments detected and antibiotic resistance pattern of these isolates was determined. Enterobacteriaceae spp. that isolated from hospitalized patients in departments of the Shahid Modarres hospital was identified by routine biochemical tests. Susceptibility testing for these species was performed according tomethod that recommended with CLSI guidelines. For detection of KPC producers the phenotypic method, Modified Hodge Test, was used as CLSI recommendation. From 1000 isolated Enterobacteriaceae spp., 76 (7.6%) isolates were resistant to Ertapenem, 84 (8.4%) isolates were Imipenem resistant and fifteen (1.5%) isolates had positive results on Modified Hodge test. The emergence of KPC producer Enterobacteriaceae and multi drug resistant species in hospitals is a major healthcare challenge and could cause an increase in both mortality and morbidity among hospitalized patients.